Page 18 - CUA Guideline on Perioperative Thromboprophylaxis and Management of Anticoagulation

Cochrane Review: Prolonged Thromboprophylaxis with

LMWH for Abdominal or Pelvic Surgery Reduces VTE

without Significantly Increasing Bleeding

• 7 RCTs (1,728 participants) comparing prolonged prophylaxis

with LMWH vs. control or placebo

Outcome Control LMWH OR (95% CI)

Overall VTE after major abdominal or
13.2% 5.3% 0.38 (0.26 to 0.54)
pelvic surgery

All DVT 12.9% 5.3% 0.39 (0.27-0.55)

Symptomatic VTE 1.0% 0.1% 0.30 (0.08-1.11)

Bleeding 2.8% 3.4% 1.10 (0.67-1.81)

Felder S, et al. Cochrane Database Ssytem Rev 2018;11:CD004318