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Disease / treatment settings










                                                Ta, Tis, T1     organ-confined

                                                                                                              Locally advanced


                                                  NMIBC               MIBC         Cystectomy/PLND         Metastatic/recurrent


                                                                            Chemoradiation



                                          -TURBT(s)                 Neoadjuvant                                1 line        2 line
                                                                                                                              nd
                                                                                                                st
                                          -intravesical Tx          cisplatin-based             Adjuvant       therapy       therapy &
                                          (BCG, chemoTx),           chemoTx in fit pts          chemoTx        (cisplatin- beyond
                                          -RC/PLND                                                             eligible or
                                          -pembrolizumab
                                                                                                               ineligible)
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