Page 6 - AUQ2022Abstracts

Résumés AUQ 2022

ultrasounds and MAG-3 diuretic renograms were reviewed. The ∆ CTT Absence of recurrence and androgen deprivation therapy in half
between the affected and normal kidney was calculated. Chi-square/ of patients treated for high-grade prostate cancers after radical
Fisher and t-tests were used for categorical and continuous data. We prostatectomy: A case for treatment de-intensification
performed ROC curves to evaluate the correlation of different CTT cutoffs Daphnée Bédard-Tremblay , Nawar Touma , Bertrand Neveu , Hélene
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with T1/2 and GWO. P-value was significant if <0.05. Hovington , Thierry Dujardin , Vincent Fradet , Yves Fradet , Michele
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Results: The pyeloplasty group consisted of 64 patients and the conserva- Lodde , Rabi Tiguert , Louis Lacombe , Paul Toren , Frédéric Pouliot 1
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tive group of 44 patients. Initial median DRF in the pyeloplasty group was 1 Université Laval - CHU de Québec, Quebec, QC, Canada
46% and 51% in the conservative group. Patients with T1/2 <5 minutes Introduction: Delaying androgen deprivation therapy (ADT) is considered
had a median CTT of three minutes, those with T1/2 5–75 minutes had a valid objective of prostate cancer (PCa)-directed therapies due to associ-
CTT of five minutes, and those with T1/2 >75 minutes had CTT of six ated side effects. For high-grade (HG) PCa, both radiotherapy (RT) plus
minutes. A cutoff of >3 minutes for CTT had the highest sensitivity to ADT or radical prostatectomy (RP) are treatment options. Unfortunately,
pyeloplasty (79.7%) but poor specificity (54.6%) (p=0.0004). CTT >5 very few descriptive data focusing on HG PCa outcomes following RP
minutes had the best specificity (95.5%, p=0.0135). A cutoff for ∆ CTT of have been published. The objective of this study was to evaluate the
≥3 minutes had the highest specificity to pyeloplasty (97.7%). For T1/2, baseline characteristics and the oncological outcomes (including avoid-
the cutoff with the highest area under the curve (AUC) on the ROC curves ance of ADT) of patients undergoing RP for HG PCa.
was CTT >5 minutes (AUC 0.84, p=0.0001) and ∆ CTT ≥3 minutes (AUC Methods: This is a retrospective study on 486 patients treated by RP
0.91, p=0.0001). For GWO, the best cut-ffs were the same: CTT >5 min for non-metastatic HG PCa at biopsy between 2007 and 2021 at CHU
(AUC 0.87, p<0.0001) and ∆ CTT ≥3 minutes (AUC 0.91, p<0.0001). de Québec. Patients were excluded if they had a salvage RP following
Conclusions: The previously suggested cutoff of CTT >3 minutes is sensi- RT, a non-prostate active cancer, less than two postoperative prostate-
tive but not specific. We identify that initial CTT >5 minutes and the specific antigen (PSA) measurements or PSA not available at diagnosis.
presence of a ∆ CTT ≥3 minutes may represent indicators of severity for Biochemical recurrence (BCR) was defined as two consecutive PSA ≥0.2
children presenting with AHN. These cutoffs may be useful for tailoring ng/mL or one PSA ≥0.2 ng/mL and treatment of recurrence. Castration-
the frequency and severity of followup imaging and may be of benefit resistant PCa (CRPC) was defined as two subsequent increases in PSA
in counselling families. with a castrate testosterone value (<1.7 nmol/L).
Results: In the 453 patients included, median age at diagnosis was 67
Swipe right on male infertility: Effect of cell phone radiation (48–85), and median PSA was 7.5 ng/mL (0.6–155). At biopsy, 61.4%
on sperm motility had ISUP grade 4 and 38.6% had ISUP grade 5. After RP, 51.1% patients
Francis Petrella , Kevin Y. Chu , Kajal Khodamoradi , Alexandra Dullea , were downgraded to ISUP 3 or less while 9.1% were upgraded to ISUP
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Ruben Blachman-Braun , John Zizzo , Ranjith Ramasamy 2 5. Positive margins were found in 53.2% patients, 65.7% patients had
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1 McGill University, Montreal, QC, Canada; University of Miami, Miami, ≥pT3, and 30.7% patients were N1. At a median followup of 49.6 months,
FL, United States 48.3% of patients were free of BCR without receiving ADT or RT. Fifty-
Introduction: Over the past decade, the relationship between humans and eight (12.8%) patients developed metastasis (median time to metastasis
their smartphones have been marked with stark symbiosis. The advent of = 21.9 months) and 38 (8.4%) became CRPC (median time from RP =
technology has prolonged the amount of time the cell phone resides in 33.0 months). At last followup, overall survival was 92.5%.
the pockets of men. This places the smartphone and its respective radio- Conclusions: Half of the patients remain free of recurrence without treat-
frequency — electromagnetic radiation (RF- EMR) — near the testicles. ment intensification after RP. Therefore, RP should be systematically
RF-EMR has been postulated to increase oxidative stress and induce free offered in fit patients and those who want to avoid ADT.
radical formation. We hypothesized that RF-EMR from cell phones has
deleterious effects on sperm parameters, though these effects can be Analyse de la qualité de vie chez les hommes à risque de
mitigated with solid mediums or distance. développer un cancer de la prostate : résultats de la cohorte
Methods: We evaluated the impact of current-generation smartphone, biomarqueurs et cancer de la prostate, prévention et
in talk mode, as the RF-EMR source. We certified the exposure to the environnement (BIOCAPPE)
specimen using calibrated RF-EMR meter. Initially, we studied the impact Roxane Tourigny , Hanane Moussa , Karine Robitaille , Vanessa
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of RF-EMR on sperm motility and viability from fertile, normozoospermic Bussières , Fred Saad , Michel Carmel , Armen Aprikian , Yves Fradet ,
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men, between the ages of 25–35 years old by exposing their semen in an BIOCaPPE-GRePEC Network, Vincent Fradet
in vitro study over an eight-hour duration. We then determined whether 1 Centre de recherche du CHU de Québec-Université Laval, Quebec,
using a cell phone case and increasing distance from semen sample would QC, Canada; Institut sur la nutrition et aliments fonctionnels (INAF)
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make a difference in outcomes. et centre NUTRISS, Université Laval, Quebec, QC, Canada; Centre
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Results: At six hours after exposure, we identified a decrease in sperm de recherche du CHUM, Montreal, QC, Canada; Centre de recherche
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motility and viability in samples exposed to RF-EMR as compared to those du CHUS, Sherbrooke, QC, Canada; Institut de recherche du CUSM,
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samples that were not from fertile controls. With the addition of the case, Montreal, QC, Canada
we noted a smaller impact on total sperm motility and viability (p=0.01, Introduction : Le cancer de la prostate (CaP) est le cancer le plus fréquent
p=0.01) as compared to direct RF-EMR exposure. In fact, moving the cell chez les hommes au Canada et affecte la qualité de vie (QdV) de façon
phone away by three inches represented the best mitigation strategy to importante. Peu d’études se sont intéressées à la QdV des hommes à
deleterious effects on sperm motility and viability. Interestingly, when the risque de CaP et aucune n’a été réalisée au Canada. Notre objectif visait
phones were turned on in the talk mode, the most detrimental effects on à faire une analyse descriptive complète de la QdV dans une cohorte
sperm motility were identified. canadienne d’hommes à haut risque de développer un CaP, et à évaluer
Conclusions: In this pilot study, we observe that the sperm parameters l’impact des problèmes urinaires et érectiles sur la QdV générale.
of motility and vitality are impacted with RF-EMR exposure from cell Méthodes : La QdV a été récoltée chez 2053 hommes à risque de CaP par-
phones. Precautionary measures, such as physical shields and increased ticipant à l’étude observationnelle prospective multicentrique BIOCaPPE,
distance from the scrotum, dampened the effects of RF-EMR. Further in qui vise à évaluer l’impact de certains biomarqueurs liés aux habitudes
vivo research on the true impact of cell phone radiation on male fertility de vie sur l’incidence du CaP. Les participants ont rempli plusieurs ques-
potential is warranted. tionnaires validés afin d’évaluer leur QdV générale (Échelle d’anxiété et
de dépression [HADS] et 36-item Medical Outcomes Study Short Form
Health Survey [SF-36]), et celle spécifique au CaP (Score international
des symptômes de la prostate [IPSS] et Inventaire de la santé sexuelle
pour hommes [SHIM]).
S206 CUAJ • Décembre 2022 • volume 16, numéro 12S3