Page 8 - AUQ2022Abstracts

Résumés AUQ 2022

with these results, urologists will reflect on their tendencies when pre- Méthodes : Nous avons découvert un nouveau rôle pour IKKe dans le
scribing sick leave. Although the appropriate length of sick leave may be fonctionnement des voies de réparations des dommages à l’ADN dans le
difficult to standardize, recommendations by a consensus panel would CRPC. Nous avons par conséquent examiné le potentiel thérapeutique de
be greatly valuable. l’amlexanox combiné à l’olaparib, un inhibiteur de PARP.
Résultats : L’association de l’amlexanox avec l’olaparib diminue la prolif-
Partial gland ablation with high-intensity focal ultrasound impact ération des cellules CRPC et augmente les dommages à l’ADN. L’olaparib
on genitourinary function and quality of life: A single-center inhibe le recrutement et l’expression de Rad51 dans les cellules CRPC
pilot experience ainsi que dans la lignée PC-3 déplétée d’IKKe. Nous avons démontré
Ioana Fugaru , Gautier Marcq , Alexis Rompré-Brodeur , Joseph que l’activité du promoteur de Rad51, mesurée par essai luciférase, était
2
1
1
Moryousef , Andrew Meng , Oleg Loutochin , George Loutochin , diminuée par l’amlexanox ou par la déplétion d’IKKe, et que le traite-
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3
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Maurice Anidjar , Frank Bladou , Raphael Sanchez-Salas 1 ment à l’amlexanox diminuait la fixation de C/EBP-β sur ce promoteur.
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1 Division of Urology, Department of Surgery, McGill University, Montreal, Notre modèle de souris a également montré que l’amlexanox combiné
QC, Canada; Department of Urology, Claude Huriez Hospital, CHU à l’olaparib inhibait la croissance tumorale des xénogreffes de CRPC.
2
Lille, Lille, France; Faculty of Medicine, McGill University, Montreal, Conclusions : Notre étude a mis en évidence un nouveau rôle potentiel
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QC, Canada; Department of Urology, Pellegrin University Hospital, pour IKKe dans la réparation des dommages à l’ADN par la régula-
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Bordeaux, France tion de la transcription de Rad51 et justifie l’association potentielle
Introduction: Partial gland ablation (PGA) using high-intensity focal de l’amlexanox avec l’olaparib dans le traitement des patients atteints
ultrasound (HIFU) is an emerging option for localized prostate cancer de CRPC.
(PCa). This pilot study assessed quality of life (QoL) outcomes during the
implementation of PGA-HIFU at a single institution. Urethroplasty surgical wait-times during COVID-19: From bad
Methods: We prospectively enrolled 25 men with a diagnosis of local- to worse
ized low/intermediate-risk PCa who elected to undergo PGA-HIFU in a Laurianne Rita Garabed , David-Dan Nguyen , Daniel Liberman 1
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1
pilot study at our institution between 2013 and 2016. Patients underwent 1 Centre Hospitalier de l’Université de Montréal, Montreal, QC, Canada;
pretreatment multiparametric magnetic resonance imaging and transrectal 2 University of Toronto, Toronto, ON, Canada
ultrasound-guided biopsies. The primary endpoints were impact on QoL, Introduction: Wait times for urethral reconstruction for strictures are
erectile and urinary function, assessed at one, three, six, and 12 months significant, and the COVID-19 pandemic significantly affected operat-
following PGA. ing room prioritization; however, there are no published studies on the
Results: The median age was 64 years old (IQR 59.5–67). Baseline specific impact of the pandemic on reconstructive urethral surgery wait
median International Index of Erectile Function-15 (IIEF-15) score was times and outcomes. We aimed to compare surgical wait times before
50, which decreased to 18 at one month (p<0.001), returned to baseline and during the COVID-19 period, as well as to compare characteristics
by three months and thereafter. International Prostate Symptom Score and surgical outcomes of patients.
(IPSS) median at baseline was 8, which worsened to 12 at one month Methods: In this retrospective study, 147 male patients with a ureth-
(p<0.05), and subsequently improved thereafter. On the UCLA-Expanded ral stricture treated with a urethroplasty or perineal urethrostomy (PU)
Prostate Cancer Index Composite urinary function, there was a decrease between September 2016 and April 2021 were included. Patients were
in median score from 92.7 at baseline to 76.0 at one month (p<0.0001), divided based on their surgery date (before/after Quebec lockdown
which improved to or above baseline afterwards. QoL remained similar on March 13, 2020). Median patient followup was 426 days. Baseline
to baseline at each followup period, as assessed via the EQ-5D ques- and surgical characteristics, and postoperative outcomes and surgical
tionnaire, its visual analogue scale, and the Functional Cancer Therapy- wait times were compared between the two groups, using the t-test, the
Prostate scores. At systemic control biopsies six months after treatment, Pearson Chi-squared test, and the Wilcoxon rank-sum.
12/25 (48%) of patients still had clinically significant cancer (GGG ≥2). Results: Median surgical wait times during the COVID-19 period were
Conclusions: This is the first cohort of men who underwent PGA-HIFU significantly prolonged (577 vs. 332 days, p<0.001). There was no dif-
at our institution. Patients demonstrated a slight, but transient, deteriora- ference in baseline characteristics between the two groups. There was
tion in urinary and erectile function at one month. QoL metrics were a greater proportion of PUs performed after March 13, 2020 (p=0.003).
not impacted during followup over one year. Although the QoL profile The stricture recurrence rate at three months postoperatively was lower
of PGA is favorable, oncological control remains to be improved, given during the COVID-19 period (20.4% vs. 2.3%, p<0.001). This one-center
the high rates of persistent GGG ≥2. study is limited because of its shorter followup period for patients who
had their surgery in the COVID-19 period.
L’amlexanox, un inhibiteur de IKK epsilon, favorise la sensibilité Conclusions: Our results show longer surgical wait times and better suc-
à l’olaparib via la regulation de la transcription de RAD51 dans cess rates during the COVID-19 period, with no significant differences
le cancer de la prostate resistant a la castration in baseline characteristics between the patient groups.
Fayrouz Annab , Sophie Gilbert , Benjamin Péant , Anne-Marie Mes-
1, 2
1,2
1,2
Masson 1,2,3 , Fred Saad 1,2,3 Utilization trends of novel hormonal agents in metastatic
1 Centre de recherche du Centre hospitalier de l’Université de Montréal castration-resistant prostate cancer in Quebec
(CRCHUM), Montreal, QC, Canada; Institut du cancer de Montréal, Jason Hu , Armen Aprikian , Ramy Saleh , Alice Dragomir 1
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Montreal, QC, Canada; Department of Surgery, Université de Montréal, 1 Division of Urology, McGill University, Montreal, QC, Canada; Division
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Montreal, QC, Canada of Medical Oncology, McGill University, Montreal, QC, Canada
Introduction : Chez un patient sur quatre, le cancer de la prostate (PC) Introduction: The introduction of novel hormonal agents (NHAs), such as
va finir par développer une résistance à la castration (CRPC). Les patients abiraterone acetate (ABI) and enzalutamide (ENZ), for metastatic castra-
souffrant de CRPC sont traités par hormonothérapie ou chimiothérapie. tion-resistant prostate cancer (mCRPC) was an important milestone given
Cependant, ces médicaments ne sont efficaces qu’un temps, et la their survival benefits, tolerability, and ease of administration relative to
découverte de nouvelles approches thérapeutiques est primordiale pour taxane chemotherapies. This descriptive study sought to examine the
améliorer la survie des patients. Nous avons récemment montré que utilization trends of these NHAs in patients with mCRPC in the early
l’inhibition de l’activité de la kinase IKKe, par déplétion ou via les inhibit- years after approval in the province of Quebec.
eurs BX795 et amlexanox, diminue la prolifération cellulaire in vivo et in Methods: A retrospective, population-based cohort was extracted from
vitro de lignées CRPC. Les inhibiteurs d’IKKe induisent également un phé- Quebec public healthcare administrative databases. The cohort included
notype de sénescence accompagné d’une forte augmentation des dom- first-time users of NHAs (ABI or ENZ) from 2011–2016. The primary
mages à l’ADN et d’une instabilité génomique dans les cellules CRPC. analysis aimed to describe the overall temporal trends (2011–2016) of
S208 CUAJ • Décembre 2022 • volume 16, numéro 12S3