Page 7 - CUA Adv Prostate Ca Drug Acccess Listing
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BRITISH COLUMBIA                                                                                                                                        Link to Patient Assistance Programs


                            Funding:
                            Medications for active cancer treatment are funded by BC Cancer for all BC Medical Services Plan patients (including First Nations Health Authority clients). These medications are
                            supplied at no charge to registered BC cancer patients at BC Cancer Centres and Clinics.
                            Patients may also have private drug plans that cover some or all of medication costs.

                            Formulary:
                            British Columbia Cancer Agency Benefit Drug List
                            http://www.bccancer.bc.ca/systemic-therapy-site/Documents/Policy%20and%20Forms/Benefit%20Drug%20List.pdf



                             DRUG                                 Strength,                                                                                                                       References
                             (Brand Name)       Indication        Route          DIN           Provincial Funding Eligibility Criteria
                             Manufacturer

                                                                                               A BC Cancer Compassionate Access Program request must be approved prior to treatment.    1.  BC Cancer
                                                                                                                                                                                              1
                                                                                               Restricted funding*                                                                                     Protocol
                                                                                                                   2
                                                                                                                                                                                                       UGUPABI [8-
                                                                                               Eligibility :                                                                                           21]
                                                                                                          1
                                                                                               •    mCRPC who are chemotherapy naïve or have received prior chemotherapy containing               2.  BC Cancer
                                                                                                    docetaxel                                                                                          Benefit Drug
                                                                                               •    ECOG PS 0-2                                                                                        List [9-21]
                                                                                               •    Life expectancy > 3 months
                                                                                               •    Adequate renal/liver function and serum potassium levels

                                                mCRPC             Tablet         Not           •    Patients are eligible to received abiraterone OR enzalutamide OR apalutamide but not
                                                                                 specified          sequential use of these agents

                                                                                                           1
                                                                                               Exclusions :
                                                                                               •    Bilirubin > 1.5 x ULN, AST or ALT > 2.5 x ULN
                             Abiraterone                                                       •    Uncontrolled hypertension (systolic BP > 160 mmHg or diastolic BP > 95 mmHg)
                             (Zytiga)                                                          •    Active or symptomatic viral hepatitis or chronic liver disease
                             Janssen                                                           •    History of adrenal dysfunction
                                                                                               •    Clinically significant heart disease (LVEF < 50% at baseline)
                                                                                               •    Patients who progressed on apalutamide or enzalutamide in nmCRPC are not eligible to
                                                                                                    receive abiraterone

                                                                                                                                                                                              1
                                                                                               A BC Cancer Compassionate Access Program request must be approved prior to treatment.    1.  BC Cancer
                                                                                                                   2
                                                                                               Restricted funding*                                                                                     Protocol
                                                                                                                                                                                                       UGUMCSPAB
                                                                                               Eligibility:                                                                                            I [9-21]
                                                                                               •    mCSPC, chemotherapy naïve or received prior chemotherapy containing docetaxel                 2.  BC Cancer
                                                                                 Not
                                                mCSPC             Tablet                       •    No prior ADT or ADT for not > 6 months for mCSPC                                                   Benefit Drug
                                                                                 specified
                                                                                               •    Should have ECOG PS 0-2                                                                            List [9-21]
                                                                                               •    Should have serum potassium > 3.5 mmol/L

                                                                                               Patients treated with abiraterone for mCSPC and develop mCRPC are eligible to receive
                                                                                               enzalutamide (but not abiraterone),







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