Page 12 - FLIPBOOK

Maximal Suppression of T is Clinically Meaningful

• ADT effect is androgen deprivation of the

tumour

• Block stimulation of tumour

• lower T to castrate levels MED

• add antiandrogen to block AR

• Newer targeting agents lower

T activity at the AR by LOW HIGH

• Inhibition of T synthesis

• Inhibition of receptor binding Testosterone Levels

Androgen deprivation of the tumour requires a strong foundation of ADT

Crawford ED, et al. Prostate Cancer Prostatic Dis 2019;22:24–38