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The Prostate Cancer Landscape







                                                                                              Docetaxel
                                                                                             Abiraterone

                                                                                            Enzalutamide
             ARAT/CYP17 Inhibitor         Radiopharmaceuticals                              Apalutamide
             Chemotherapy                 PARP inhibitor                                        NEWLY

             ADT                                                                             DIAGNOSED
                                                                                                mHSPC


                                                                                               PRIMARY
                                                                                            PROGRESSIVE
           LOCALIZED OR LOCALLY                              BIOCHEMICAL                        mHSPC                                                       TERMINAL DISEASE

                   ADVANCED                                                                                                   mCRPC
              PROSTATE CANCER                                RECURRENCE                                                                                            (DEATH)

                                                                                               nmCRPC                       Docetaxel

                                                                                                                           Cabazitaxel
                                                                                            Enzalutamide
                                                                                            Apalutamide                   Abiraterone

                                                                                            Darolutamide                 Enzalutamide
                                                                                                                            Olaparib
                                                                                                                          Radium 223

                                       Androgen Deprivation Therapy (ADT) – Foundation of Care (LHRH Agonist or Antagonist)



                   ARAT Androgen-receptor axis-targeted agents LHRH Luteinizing hormone-releasing hormone
                   mHSPC Metastatic hormone sensitive prostate cancer
                   nmCRPC Non-metastatic castration resistant prostate cancer mCRPC Metastatic CRPC
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