Page 9 - FLIPBOOK

Androgen Receptor (AR) Signalling Pathway

Androgens (T) are produced at 3 sites Testes Adrenal glands

• Testes Reducing T to bind and activate the AR
decreases tumour cell proliferation
• Adrenal glands

• Prostate tumour cells Testosterone/DHEA

(occasionally) 5-reductase

HSP
In the eugonadal state, 95% of androgens are

produced by the testis HSP DHT DHT
Nuclear AR Nucleus

HSP HSP AR translocation AR
dissociation DHT
HSP AR

DHT

Lamb AD, et al. Trends Urol Mens Health 2013;4:26-30
National Cancer Institute. https://www.cancer.gov/types/prostate/prostate-hormone- therapy-fact-sheet.
AR Androgen receptor DHT Dihydrotestosterone Accessed February 1, 2021
HSP Heat shock protein T Testosterone Figure adapted from ©Bandyopadhyay M, Muthuirulan P. J Drug Des Devel 2017;1:1-10