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BRCA Mutations Are Associated with Rapid Progression to

Metastatic Disease and Higher Risk of Mortality

BRCA mutation associated with rapid progression to metastatic disease and higher risk of mortality (5-year data)

Developed metastases Cause-specific survival from metastatic disease

1.0

40%
Cause-Specific Survival (%)
P <0.001 0.8

23% 0.6

20% 0.4

7% 0.2 Median, yrs (CI 95%)
Noncarriers NR*
BRCA 11.3 (6.8-15.8) P < .001
0% 0

BRCA mutation Control 0 2 4 6 8 10 12 14 16 18 20
Years

BRCA, breast cancer gene
Castro E et al. J Clin Oncol 2013;31:1748-57.