Page 11 - Flipbook

Implications for Carriers of BRCA1/2 Mutation:

Prognosis and Familial Risk

• Increased relative risk for prostate cancer by age 65

• 2.5-8.6 fold vs noncarriers 1-3

• Increased risk for other cancers at a younger age:

• Breast, pancreatic, melanoma

• Increased familial risk for cancer(s)

Risk for more aggressive disease 4,5

• Higher Gleason score

• More nodal involvement and distant metastases at diagnosis

• Higher likelihood of developing metastatic disease at 5 years

• Higher risk of prostate cancer-specific mortality

1. Breast Cancer Linkage Consortium J Nat Cancer Inst 1999;91:1310-6. 2. Kote-Jarai Z et al. Br J Cancer 2011;105:1230-4.
3. van Asperen CJ et al. J Med Genet 2005;42:711-9. 4. Castro E et al. Eur Urol 2015;68:186-93. 5. Castro E et al. J Clin Oncol 2013;31:1748-57.