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Integrating Olaparib in mCRPC










                                                                                                                                                                            Treatment not
                                                     ADT + ARAT                                                                                                              yet received
                                                                                                                                                                                    or
           nmCRPC                                                                    Progress                        Docetaxel or Radium               Progress

                                                                                    to mCRPC                             Olaparib if HRRm                                      Olaparib
                                                                                                                                                                               if HRRm






                                                                                                                                                                            Treatment not
                                                                                                                                                                             yet received
                                                                                                                                                                                    or

                                                         ADT + Docetaxel             Progress                                Abi or Enza               Progress                Olaparib
                                                                                                                           CBZ or Radium                                       if HRRm
                                                                                    to mCRPC


             Metastatic

                                                                                                                                                                             Treatment not
           CSPC or CRPC                                                                                                                                                        yet received
                                                              ADT + ARAT             Progress                        Docetaxel or Radium                                             or


                                                                                    to mCRPC                             Olaparib if HRRm              Progress                 Olaparib

                                                                                                                                                                                if HRRm




    Personal slide Saad F : Adapted CUA guidelines for CRPC 2021, CUAJ 2021                                         Choice based on Level 1 evidence
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