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1 in 10 Men with mCRPC have Germline Mutations
Distribution of presumed pathogenic • Inherited germline DDR mutations
germline mutations
• mCRPC: 11.8% (82/692)
• Localized disease: 4.6% (23/499)
RAD51C 1%
MSH6 1% MRE11A 1%
MSH2 1%
BRIP1 1% Presumed pathogenic germline mutations
GEN1 2% FAM175A 1%
PMS2 2% in metastatic cases (N = 692)
NBN 2%
ATR 2% Gene No. of Mutations % of Men
RAD51D 4%
PALB2 4% BRCA2 37 5.35
BRCA2 44%
BRCA1 7% ATM 11 1.59
CHEK2 12% CHEK2* 10 1.87
BRCA1 6 0.87
ATM 13%
*n = 534; data censored for metastatic cases with inadequate sequencing
DDR, DNA damage response
Pritchard CC et al. NEJM 2016;375:443-53.